European scientists use the "genetically modified epidermis" to rejuvenate the skin

"GMO epidermis" rejuvenates the skin

Later research shows that its function is completely normal

According to a medical research paper published in the British journal Nature, European scientists have reconstructed about 80% of the skin of a 7-year-old borderline bullous epidermolysis (JEB) patient by transplanting transgenic epidermal cultures. And later studies have shown that their skin functions are completely normal.

Borderline bullous epidermolysis is a serious genetic disease that can cause skin relaxation, often fatal. Previous studies have shown that mutations in the gene called LAMA3, LAMB3 or LAMC2 affect laminin 332, a component of the epidermal basement membrane, leading to bullous and chronic wounds in the patient's skin. The disease not only seriously affects the quality of life of patients, but may also cause skin cancer.

In the past, treatment of two patients demonstrated that transplanted transgenic epidermal cultures, a genetically engineered epidermal cell population, were able to produce a functionally normal epidermis and repair skin lesions in borderline bullous epidermolysis. But in the past, only a small area of ​​skin can be reconstructed.

This time, in the face of a 7-year-old patient, the team of scientists at the University of Modena Reggio Emilia in Italy used the skin cells of the patient's body without the bullous area to culture the primary keratinocytes and then use the retroviral vector. It was genetically engineered to inhibit the non-mutated form of the LAMB3 gene, thereby reconstructing the epidermis. Subsequently, the researchers applied a transgenic epidermal graft to the prepared dermal wound site to cover the patient's affected body surface.

Over the next 21 months, the team found that its regenerated epidermis adhered tightly to the underlying dermis and even healed after induction of mechanical stress, without the formation of bullae.

The authors of the paper found through cloning that these human epidermis are maintained by a limited number of long-lived stem cells, which are generally self-renewing, producing progenitor cells and supplementing the newly differentiated keratinocytes. (Technology Daily)

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