MD application case sharing: pre-clinical cytotoxicity test

Rapid, efficient, and reliable early prediction of toxicity in vitro is critical for drug development and reducing the risk of drug clinical trials. In order to improve the scientific predictability of early toxicity of new drugs, the early pre-clinical and clinical safety evaluation of drug toxicology early research mode was changed to toxicology and pharmacology and pharmacodynamics of new chemical entities (NCEs) at the new drug discovery stage. Screening and optimization of the combination of science and pharmacokinetics, screening for candidate new drugs with low toxicity for follow-up research, which has become a new research and development idea for major pharmaceutical companies in the West, that is, drug toxicology research runs through new drug discovery and clinical practice. Pre-safety assessment, clinical trials, and post-marketing surveillance and tracking throughout the process.

Utilizing the new progress of modern life sciences, the establishment, application of new technologies, new methods and new models for preclinical safety evaluation and toxicological mechanism research of new drugs has become a new trend in the development of new international drugs. The High Connotation Screening (HCS) system is an automated, high-resolution microscope that performs high-throughput analysis of changes in cell morphology or biochemical properties. With the help of automated HCS, we were able to quickly screen out libraries of toxic compounds, which is a necessary step in the development of new drugs. As technology continues to evolve, HCS systems are becoming faster, more flexible, and more sensitive.