Release date: 2017-11-16
If it burns in the house, the smoke detector will remind us to protect our lives. Researchers in Dresden have now developed a molecular smoke alert that targets the most important human cancer gene, the TP53 gene. If the TP53 gene is mutated in the cell, the alarm will continue. Molecular smoke detectors work like TP53 sensors to monitor the correct function of genes. A non-functional TP53 gene activates the sensor, triggering cell death. The results of the research team from Professor Frank Buchholz are now published in the journal Nature Communications.
Cancer is caused by changes in the human genome. Mutations in oncogenes and tumor suppressor genes are cumulatively unrecognized over time and ultimately lead to uncontrolled cell proliferation. Among the 50% of all human tumors, the tumor suppressor gene TP53 is no longer the most functional mutant cancer gene. University of Dresden - University of Cancer Hospital's University Cancer Center UCC scientist Carl Gustav Carus, National Cancer Center NCT Dresden and German Cancer Alliance DKTK Dresden concluded that the formation of TP53 sensors can inhibit tumor formation at an early stage.
To achieve this, they designed a genetic component that makes cell function dependent on normal TP53. If the TP53 function is interrupted, the sensor is activated and initiates cell death. "We have been in the cancer cell for a long time after the transformation process," MD said. Frank Buchholz described the current situation. Therefore, treatment is often too late to eliminate all cancer cells in the body. In addition, therapeutically resistant clones rapidly emerge from some cancer cells due to other mutations.
“The TP53 sensor is the first to achieve active precocious intervention. Our results suggest that TP53 mutant cells can be selectively detected and eliminated at an early stage, thus avoiding the transformation process. The researchers plan to use their initial findings to develop new cancer diagnoses. And establish a long-term anti-cancer mutation protection system.
Source: Noble
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