How intestinal microbes cause heart disease
August 16, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];In the past five years, some scientists have reminded not to eat eggs and meat, because these foods produce a common dietary compound called trimethylamine oxide (TMAO), which plays an important role in heart disease. Recently, in a research report published in the international magazine Molecular Nutrition and Food Research , the researchers raised new questions about whether TMAO circulating in the body can cause heart disease and whether TMAO can be used as a disease. Biomarkers.
The level of TMAO in fish is higher, and in humans, the intestinal bacteria known as the thick-walled bacteria can convert the nutrients in eggs and the carnitine in meat into TMAO; in this study, The researchers found that healthy males with elevated levels of TMAO after ingesting eggs and beef also contained higher levels of thick-walled bacteria. Researcher Marie Caudill said that in this study we found that the individual gut microbiome affects the level of circulating TMAO in the body. However, TMAO plays an important role in the progression of the disease. To this end, we want to know if it is intestine. The microbiome also plays an important role in the progression of the disease, not just the TMAO.
In 2011, researchers conducted a study to analyze the blood of patients with cardiovascular disease, and found that the patient's body contains a high level of circulating TMAO, the next study shows that TMAO is also involved in the formation of mouse arterial plaque. In the process, previous studies have also shown that women who have colon cancer have accumulated a high level of TMAO five years before the early stage of cancer; therefore, more and more research evidence reminds people to eat less fish. , eggs and meat.
Researchers want to know that although years of research have shown that large intakes of fish can help reduce heart disease, is TMAO a causative factor in heart disease? In the current study, researcher Caudill and colleagues conducted a dietary trial of 40 healthy young men who were asked to consume four different diets, including: fish (6 ounces of squid) and eggs (three boiled) Cooked eggs), meat (6 ounces of beef patties), and fruit group (apple sauce) as a control; the subjects randomly took one of the diets every day for a week, before each meal, the researchers collected Participants' feces were used to analyze the composition of their gut microbiota, while blood and urine were collected to determine the level of TMAO. The investigator then collected the participants' blood and urine 6 hours after the meal and determined the level of TMAO.
The results of the study showed that men with elevated levels of TMAO in the body after ingestion of meat and eggs often had higher levels of thick-walled bacteria in the intestine, while those with lower levels of TMAO had a class of bacteria named bacteriodides. High; thick-walled bacteria can express genes that convert choline in eggs and carnitine in beef into TMAO, which can help the body produce TMAO, but the diversity of intestinal microbiota in individual organisms with higher levels of TMAO Often lower. Compared with men who consume eggs and beef, when individuals ingest fish, the level of TMAO in their body increases by 50 times in 15 minutes, but in the United States, fish is not the main thing in people's daily life. Part of the diet, people eat more eggs and meat.
Researcher Caudill said that the study shows that the increase in TMAO levels may be just a biomarker that distinguishes differences in individual gut microbiota. We speculate that individuals (such as cancer, heart disease and other chronic diseases) are compared to healthy individuals. There are completely different groups of gut microbes in the body, and these groups of microbes can be labeled by TMAO levels in the blood.
In future research, researchers will examine the role of the gut microbiota in the pathogenesis of heart disease, and look for ways to reduce the level of TMAO circulating in the body, while observing whether lowering the level of TMAO can help reduce heart disease in individuals. Risk of onset.
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