Local environment has a greater impact on gene expression than genetic background
March 27, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];According to a genetic research report published by the British journal Nature Communication, Canadian scientists conducted an analysis of thousands of individuals in the same region and in different regions, showing that exposure to local environmental factors, such as air pollution, is better than Genetic background has a greater impact on regulating gene expression and health.
The increase in industrialization and fossil fuel use has led to air pollution in many parts of the world, where inhalable particulate matter is the primary pollutant in many cities and regions, while inhalable particulate matter enters the body primarily through the respiratory tract. In the past, it was thought that people with different genetic backgrounds (when studying a gene with a specific trait, the rest of the DNA in the genome is the genetic background of the gene) have different responses to environmental factors, so the individual's heritability against specific diseases. And the risk of illness is also different. However, the risk of disease caused by environmental exposure and the interaction of environmental exposure with the genome has not yet been fully understood by humans.
For this reason, Philip Avodara, a scientist at the Ontario Cancer Institute in Canada, and colleagues collected and evaluated environmental exposure, health, gene expression levels, and genome-wide genetic differences from 1,007 subjects from different regions of Quebec. Information and other data.
Through investigation and analysis, the research team found that the effect of the environment exhibited by blood samples on gene expression is greater than the influence of genetic background on gene expression. In addition, local environmental air pollution, such as fine particulate matter (PM2.5), nitrogen dioxide and sulfur dioxide, regulates the expression of genes that affect cardiovascular metabolism and respiratory characteristics in humans, and they may cause lung disease. And arteriosclerosis.
The research team concluded that the new findings show how the local environment directly affects the individual's disease risk, and also found that genetic differences can modulate an individual's response to environmental challenges. (Reporter Zhang Mengran)
Editor-in-chief
A genome is like a score, and what kind of music is played is not just a score decision. The complex interaction between genes and the environment leads to the health or disease of the organism, and the reason is basically unclarified. Perhaps soon, with the power of big data, genetic testing can tell a person's health tips that are most critical to him. The achievements of this Canadian scientist are a beginning.
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