Nanoprobe captures residual tumor cells to prevent postoperative tumor recurrence and prolong survival
September 10, 2018 Source: Health News
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, Xiao Zeyu's research group of Shanghai Jiaotong University School of Basic Medicine published a research result online in the well-known journal of Nanomedicine, "National Chemistry Society Nanomaterials". This study constructed an integrated diagnosis and treatment system based on gap-enhanced Raman probe, which can detect residual micro-tumor cells with high specificity and sensitivity in the operation, and at the same time can perform photothermal therapy to remove residual microscopic tumor cells to avoid postoperative tumors. The recurrence.
Currently, surgical resection remains the most effective treatment for cancer. However, in many invasive or metastatic cancers, the boundaries of the tumor are not clearly defined, and tumor growth infiltrates surrounding vital organs or neural structures. In this case, even an experienced surgeon cannot completely remove the tumor by surgery, leaving residual tiny tumors. These residual tiny tumors can cause fatal tumor recurrence and metastasis. Therefore, how to achieve the detection and eradication of these residual microscopic tumors during surgery is crucial for the treatment of cancer.
Xiao Zeyu's research team has established a gap-enhanced Raman nanoprobe to integrate the diagnosis and treatment, to achieve high sensitivity and specific detection during surgery and to eradicate residual microscopic lesions. The Raman nanoprobe has a two-layer core-shell gold nanostructure, and a double-layer gold internal gap junction is embedded in the Raman reporter molecule. This nanostructure produces high-sensitivity, high-specificity Raman imagery when used with a 785 nm laser for microscopic tumor detection, and produces thermotherapy for photothermal ablation when switching 808 nm laser for microscopic tumor removal. . In the in situ prostate metastasis tumor model, the Raman nanoprobe probe successfully achieved accurate imaging and complete removal of residual microscopic tumors around the operating bed without damaging normal tissue. The results of the study showed that the Raman image-mediated photothermal removal based on the probe can prevent postoperative tumor recurrence and metastasis and significantly prolong the survival of mice. This research expands Raman imaging for in vivo biomedical applications for integrated therapy. (Special correspondent Yang Jing)
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