Release date: 2009-08-14
According to Japanese media reports, starting from late August, the University of Tokyo Affiliated Hospital will conduct a clinical trial of transgenic virus for the treatment of malignant brain tumors to study the effectiveness of this therapy, which is the first in Japan.
Researchers will choose highly malignant glioblastoma as the treatment target. This type of tumor grows fast and has a short course of disease. It usually relies on surgical removal of the tumor before radiotherapy and chemotherapy. Even so, patients can only live for 12 to 14 months on average, and if the tumor recurs, the patient can only live for 5 to 9 months.
To cope with this malignant brain tumor, the researchers used a herpes virus that is susceptible to cancer cells and genetically engineered it to reduce the effects on other normal cells and focus on "firepower" to attack cancer cells.
The researchers said that the researchers will recruit patients with relapse of glioblastoma, who will inject the transgenic herpes virus into the tumor site twice in half a month, then observe changes in tumor size, and whether or not there is nerve paralysis. symptom. The trial will last for two years.
Some experts believe that transgenic viral therapy may be the most effective and safe way to deal with malignant brain tumors in the future. In 2005, American scientists published a paper in Cancer Research, saying that they used a transgenic virus to treat experimental mice transplanted with human malignant brain tumors, which significantly prolonged the life of the rats without damaging healthy cells. Meditech Medical Network
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