â–¡ The reporter Zhang Shuanghu biosensor has also played an increasingly important role in the medical field. Clinically, biosensors such as immunosensors are used to detect various chemical components in body fluids, providing a basis for doctors' diagnosis.
Under the support of the National Natural Science Foundation of China and the Youth Foundation Project of the Institute of Physics and Chemistry of the Chinese Academy of Sciences, the research team led by Tang Fangqiong, a researcher at the Physical and Chemical Research Institute of the Chinese Academy of Sciences, used water-soluble cadmium telluride quantum dots prepared by ultrasonic atomization to achieve the activity of lactate dehydrogenase (LDH). Qualitative and quantitative analysis.
A few days ago, the research results published two papers in the journal Biosensors and Bioelectronics, the number one influential factor in the field of electrochemistry and sensors. Related work has applied for two Chinese invention patents.
Expanding the Application of Nanomaterials Biosensors have been used to monitor a wide range of bacteria, viruses and their toxins. Biosensors can also be used to measure various amino acids such as acetic acid, lactic acid, lactose, uric acid, urea, antibiotics, glutamic acid, and various carcinogenic and mutagenic substances.
Lactate dehydrogenase is present in the cytoplasm of all tissue cells in the body and has a certain normal range. Abnormal metabolism, the occurrence of lesions will cause changes in lactate dehydrogenase content. Therefore, the development of a new, rapid, and efficient method for detecting the level of lactate dehydrogenase activity can achieve early diagnosis and real-time regulation of common myocarditis, myocardial infarction, nephropathy, and liver cancer.
"But it will have a wide excitation range, a narrow emission spectrum, and a high fluorescence quantum yield. It can adjust the size, composition, or structure to adjust the emission peak. Quantum dots with excellent optical properties such as multi-color luminescence are used for the development of large-capacity information. Fast response, high sensitivity, easy operation, low cost, and portable biosensors have become new hot spots for optical biosensor research, said Ren Xiangling, a member of the Chinese Academy of Sciences Physics and Chemistry Research Institute.
Tang Fangqiong’s lab for controlled preparation and application of nanomaterials has been dedicated to the preparation of quantum dots using low-cost, engineerable methods and their application to biochemical detection. Water-soluble cadmium telluride (CdTe) quantum dots prepared by ultrasonic atomization Achieve qualitative and quantitative analysis of lactate dehydrogenase activity. Their new biosensors have a detection range of 150 to 1500 U/L and a detection limit of 75 U/L.
The researchers then extended this method to the determination of serum glucose concentrations and initially achieved simultaneous detection of these two substances. Compared with other quantum dot optical biosensors (eg, optical biosensors based on fluorescence energy resonance transfer), the novel optical biosensors they construct do not require expensive and complicated biochemical molecular modifications. The method is simple and quick, and the operation is easy to grasp. This method expands the application field of nanomaterials, provides a reference for experimental and theoretical basis for the development of new ways of biochemical detection and analysis, and promotes the practical development of enzyme biosensors.
"Our goal is family-oriented"
“The sensors used to detect lactate dehydrogenase are often complicated to prepare, require some complex molecules, or require modification of the enzyme itself, which takes a day or two or more, and requires specially trained people to operate. The detection system can be directly formulated with commercially available enzymes, enzymes available in the medical or biological products market, and the preparation process generally takes only half an hour, said Ren Xiangling.
Most people will have a physical examination every year, but doctors think this time is too long. However, going to the hospital for medical examination is a very troublesome thing. It usually takes more than half a day to line up, register, and check, and it takes a few days to get results again. Many people are in trouble and do not go to physical examination.
"If we can make the detection equipment miniaturized, the detection method is easy to grasp, and it can be quickly detected. Checking it at home every few months will not only discover the hidden dangers of the disease, but also facilitate the residents." Ren Xiangling said, "Now the family itself Checking blood pressure, blood sugar, and testing for other indicators is relatively small, mainly because of the complexity of testing equipment technology. Our goal is to achieve a family medical examination."
The team used this new technique to perform serum tests and the results were in good agreement with the equipment commonly used in hospitals.
“To realize the family medical examination, there is still a lot of work to be done. In the future, we will consider making kits or test strips. Just like the current blood glucose meter, a test strip is used to insert a reading.†Ren Xiangling said, “This is an optical sensor. Our main areas of research are biological reagents and nanomaterials, so we also hope to work with people who conduct light sensing and optical device research to convert colorimetric readings into readings."
Under the support of the National Natural Science Foundation of China and the Youth Foundation Project of the Institute of Physics and Chemistry of the Chinese Academy of Sciences, the research team led by Tang Fangqiong, a researcher at the Physical and Chemical Research Institute of the Chinese Academy of Sciences, used water-soluble cadmium telluride quantum dots prepared by ultrasonic atomization to achieve the activity of lactate dehydrogenase (LDH). Qualitative and quantitative analysis.
A few days ago, the research results published two papers in the journal Biosensors and Bioelectronics, the number one influential factor in the field of electrochemistry and sensors. Related work has applied for two Chinese invention patents.
Expanding the Application of Nanomaterials Biosensors have been used to monitor a wide range of bacteria, viruses and their toxins. Biosensors can also be used to measure various amino acids such as acetic acid, lactic acid, lactose, uric acid, urea, antibiotics, glutamic acid, and various carcinogenic and mutagenic substances.
Lactate dehydrogenase is present in the cytoplasm of all tissue cells in the body and has a certain normal range. Abnormal metabolism, the occurrence of lesions will cause changes in lactate dehydrogenase content. Therefore, the development of a new, rapid, and efficient method for detecting the level of lactate dehydrogenase activity can achieve early diagnosis and real-time regulation of common myocarditis, myocardial infarction, nephropathy, and liver cancer.
"But it will have a wide excitation range, a narrow emission spectrum, and a high fluorescence quantum yield. It can adjust the size, composition, or structure to adjust the emission peak. Quantum dots with excellent optical properties such as multi-color luminescence are used for the development of large-capacity information. Fast response, high sensitivity, easy operation, low cost, and portable biosensors have become new hot spots for optical biosensor research, said Ren Xiangling, a member of the Chinese Academy of Sciences Physics and Chemistry Research Institute.
Tang Fangqiong’s lab for controlled preparation and application of nanomaterials has been dedicated to the preparation of quantum dots using low-cost, engineerable methods and their application to biochemical detection. Water-soluble cadmium telluride (CdTe) quantum dots prepared by ultrasonic atomization Achieve qualitative and quantitative analysis of lactate dehydrogenase activity. Their new biosensors have a detection range of 150 to 1500 U/L and a detection limit of 75 U/L.
The researchers then extended this method to the determination of serum glucose concentrations and initially achieved simultaneous detection of these two substances. Compared with other quantum dot optical biosensors (eg, optical biosensors based on fluorescence energy resonance transfer), the novel optical biosensors they construct do not require expensive and complicated biochemical molecular modifications. The method is simple and quick, and the operation is easy to grasp. This method expands the application field of nanomaterials, provides a reference for experimental and theoretical basis for the development of new ways of biochemical detection and analysis, and promotes the practical development of enzyme biosensors.
"Our goal is family-oriented"
“The sensors used to detect lactate dehydrogenase are often complicated to prepare, require some complex molecules, or require modification of the enzyme itself, which takes a day or two or more, and requires specially trained people to operate. The detection system can be directly formulated with commercially available enzymes, enzymes available in the medical or biological products market, and the preparation process generally takes only half an hour, said Ren Xiangling.
Most people will have a physical examination every year, but doctors think this time is too long. However, going to the hospital for medical examination is a very troublesome thing. It usually takes more than half a day to line up, register, and check, and it takes a few days to get results again. Many people are in trouble and do not go to physical examination.
"If we can make the detection equipment miniaturized, the detection method is easy to grasp, and it can be quickly detected. Checking it at home every few months will not only discover the hidden dangers of the disease, but also facilitate the residents." Ren Xiangling said, "Now the family itself Checking blood pressure, blood sugar, and testing for other indicators is relatively small, mainly because of the complexity of testing equipment technology. Our goal is to achieve a family medical examination."
The team used this new technique to perform serum tests and the results were in good agreement with the equipment commonly used in hospitals.
“To realize the family medical examination, there is still a lot of work to be done. In the future, we will consider making kits or test strips. Just like the current blood glucose meter, a test strip is used to insert a reading.†Ren Xiangling said, “This is an optical sensor. Our main areas of research are biological reagents and nanomaterials, so we also hope to work with people who conduct light sensing and optical device research to convert colorimetric readings into readings."
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