On February 8th at the Food and Drug Administration (FDA) Consultation Meeting on Transmissible Spongiform Encephalopathy (TSEs) held in Silver Spring, Maryland, the blood-borne Crohn's disease (vCJD), also known as the human mad cow body The assessment of potential hazards becomes the focus of the conference. The committee called for new technologies that can greatly reduce risks, and it is not necessary to make unnecessary observations of many blood donors. Pall Corporation (NYSE: PLL) showcased the latest scientific data on the company's new anti-virus technology. The "Leukotrap® Affinity Prion Reduction Filter" is expected to be launched in Europe this spring. This filter will be able to reduce prions, which are the red blood cells, and prions are most commonly found in blood transfusion equipment. Prions can cause mad cow disease and other fatal neurological destructive diseases - transmissible spongiform encephalopathy. Dr. Sam Coker, chief scientist and technical director of Pall Pharmaceuticals, acknowledged that the public health community is highly concerned about the possibility of the second large-scale mad cow disease in the world, including North America. Japan is the country that has recently been confirmed as a contagious case of mad cow disease. The uncertainty of the intervals between the discovery of infectious prions and the appearance of symptoms has added to the challenge of accurately estimating the scale of the second mad cow disease. This illness-free disease presents us with an important question: How many blood donors carrying the vCJD virus are at risk of contracting a clinical disease that is not found, and they still donate blood? Recently, mad cow disease is not allowed to be donated by people infecting the country, which will affect the availability of medical blood and will lead to blood deficiency. In the first year, a 1 percent reduction is equivalent to a reduction of 75,000 to 85,000 blood donors, not to mention the impact on the future. The reduction in the number of white blood cells used in many countries to reduce the transmission of vCJD transfusions, but only reduced the infectiousness of 42% of the transmissible spongiform encephalopathy in the blood. Pall's leukocyte capture affinity prion reduction filter was developed in response to one of the company's missions: ensuring the safety of blood sources. The filter can reduce white blood cells and other prions (whether cell-associated or non-cell-associated) and reduce infectivity before transfusion at one time. The outline of the research structure presented by Dr. Coker showed that the new technology can simultaneously reduce 99% of leukocytes and prions in the infectious body. He concluded that the new filter can reduce different infectious prion variants, including those that cause vCJD disease. His further examination of the study showed that the new filter could reduce the human mad cow prion disease of red blood cells to the extent that Western blot assays, the main standard for detecting prions, can detect them. He also discussed infectious itch prions at the outbreak in a herd at the seminar, indicating that the new filter can reduce prions to a low level that can be detected by venom western blot assays. Dr. Coker gave a detailed description of the annual scrapie prion filtration and non-filtered blood transmission infectious diseases seminar. After 300 days of research, 3 of the 18 hamsters that received unfiltered red blood cells all produced scrapie, and only two showed clinical signs and symptoms of the disease. None of the hamsters that received red blood cells produced scrapie. Dr. Coker also pointed out that the results of the study showed that the filters did not destroy red blood cells, and they did not affect their efficacy, purity, or therapeutic function. After Pall filed an application with Canadian and US regulatory agencies, it is expected that the leukocyte capture affinity prion reduction filter will be launched in Europe this spring. The company is also committed to applying basic technologies to diagnostic equipment to help diagnose bovine spongiform encephalopathy (BSE) prior to entering food supplies.
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