Concentrated pellets

Concentrated pellets are pills obtained by concentrating a portion of the medicinal material extract into a fine powder of a paste and certain medicinal materials or a suitable excipient. Also known as "medicine cream pills."
Concentrated pellets are pills obtained by concentrating a portion of the medicinal material extract into a fine powder of a paste and certain medicinal materials or a suitable excipient. Also known as "medicine cream pills." Concentrated pellets are generally considered to be an improved dosage form of the pellet. In fact, in the Jin Dynasty Ge Hong (AD 281 ~ 341) "Elbow Reserve Emergency", there have been "...to the slag, more soup, fried and can be pill..." record. The ancient "fried pill" is similar to the current concentrated pill in the preparation method and the principle of drug treatment. The latter is based on inheriting the former, improving the process of certain operations, expanding the scope of adaptation, and other Some water pills, honey pills, etc. have also been converted into concentrated pills. The concentrated pill is a better dosage form of the pill, which has certain characteristics, and the volume is greatly reduced compared with the traditional honey pill and water pill. For example, Baohe Pill, the Pharmacopoeia stipulates that its water pill should be taken 6g at a time, and 3g of concentrated pill service is equivalent to the therapeutic effect of 6g of water pill, and the dosage is half of the pill. Another example is Liuwei Dihuang Pill, Pharmacopoeia stipulates that its big honey pill will be served 9g at a time, including 4.5g of crude drug, which will be used as a concentrated pill only 2.6g, and the dosage is only 1/4 of the pill. The dosage is small and easy to take, the curative effect is increased, the carrying and transportation are convenient, and a large amount of excipients are saved, that is, it conforms to the characteristics of the traditional Chinese medicine and is suitable for mechanized production, and is also suitable for the production of the grassroots unit. However, in the process of cooking the medicinal materials or improper treatment of other medicinal materials, or the inferior smashing and pilling techniques, the effective ingredients of some medicinal materials are affected and the degree of disintegration is affected, thereby reducing the curative effect. The concentrated pill can be divided into two types according to the excipients: water pill type concentrate pill and honey pill type concentrated pill.
First, the machine instructions
   1. Before using the machine, remove the upper cover and the gear cover. A few drops of non-hydrated edible oil must be added to each oil eye, and then scrub the four rollers and the parts in contact with the pill with medical alcohol. Disinfection treatment.
2 , the upper cover, the gearbox cover is reinstalled and reset, the power is turned on, the switch is turned on, and the empty machine is rotated for 1-2 minutes.
3. The uniformed pellets will be dispensed, put into the extruder in an appropriate amount, and stripped, and then the strips will be placed into the pellets one by one and directly into pellets.
4 , coating: After the pill is made, it can be placed in a water pill coating machine, wrapped in white, red and other outerwear.
5 , drying method: After the pill is made, the pill can be dried by entering the water pill coating device for electric heating. It can also be dried by the hot air of the hair dryer, or dried directly in the sun.
6. Polishing method: Put the pill in the water pill coating machine and roll continuously. The longer the rolling time, the smoother the surface.
 
Second, the user notice
  1. This machine is suitable for ambient temperature of -5 ° C to 40 ° C, relative humidity less than 90%. There is no conductive dust and corrosive metal gas around, and it is placed in a ventilated and clean place.
2. When operating, there should be no other unrelated items on the work surface. The pelletizing machine is placed on a stable table. When the power supply voltage is confirmed, the power supply should be close to the table. The power socket must have a reliable grounding wire. It is strictly forbidden to pull the power cord hard to prevent the person from tipping over and breaking the pill. Machine and other accidents occurred.
3. After the machine is used, remove the hexagon socket head cap screws, open the upper and lower parts with the roller as the boundary, remove the four rollers, scrub with medical alcohol, and then install the reset.
4. When scrubbing with medical alcohol, when changing the pelletizing roller, the total power must be cut off and the power plug must be pulled out to avoid personal accidents.
5. When the pelleting machine is in use, it is strictly forbidden to touch the pelletizing roller with hand and brush or other tools to avoid pinching the finger. It is strictly forbidden to process the pellets under the protection of the upper cover and the gearbox cover. An unnecessary personal accident has occurred.
6. If the power cord is damaged (such as exposed bare wires), you must use a dedicated power cord. Go to the local office maintenance department to purchase replacement. In case of failure of the switch or socket, it must be stopped. It is strictly forbidden to change the line to continue to use. The opening or socket of the same specification should be replaced in time to avoid mechanical and personal accidents.
7. The crushing equipment for this machine can be selected from our LH-08B flowing water Chinese medicine crusher or XFB-400g to 500g swinging Chinese medicine crusher.
8. The water pill coating can be directly removed and washed when not in use. Rotate clockwise and pull it out. Place it in a reliable, clean place for use. Apply a small amount of clean, anhydrous cooking oil to the exposed part of the water pill to prevent rust. It is strictly forbidden to wash the whole machine or electric heater directly with water. When the unit is not in use, it must be placed in a dry, clean and ventilated place. During the use of electric heaters, it is strictly forbidden to contact with water to prevent electrical conduction and cause personal accidents such as electric shock.
 
 
Third, machine parts
 
Name
Specification
Number of accessories
Remarks
Heating plate
80 × 105mm, 1KW
1
 
power cable
0.75mm 2×1.8M
1
 
1.5mm 2×1.8M
1
 
Support tray
27cm×20cm
1
Daily necessities
Water sprinkler
0.5 kg
1
Daily necessities
 
 
Fourth, the common causes of the pill machine failure and troubleshooting methods
 
Common faults of this machine
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You must be cut off in order to do the following
1. After the unit is powered on , the motor does not run.
1. Poor contact of the power cord or loose power plug; 2. Poor contact of the switch.
1. Repair the power supply or exchange the plug of the same specification;
2. Repair or replace the same size switch.
2. When the mechanism is pill , the shaft knife rotates or the medicine surface sticks.
Discharging loose baffles, and the knife shaft zui generated from the bottom, from the pills can not be scraped off axis knife slot.
Adjust to the distance between the discharge plate and the bottom of the shaft sipe , (about 0.1mm ) and tighten the set screws.
3. When the unit is working , the motor stops suddenly.
1. Capacitance is broken.
2 , the gear is stuck.
Check the gear slots for debris and clean them.
4. When the machine is working , the shaft cutter has a slight jump.
Loose block screw loose
Open the cover, the inner hexagon screw 6 tightened evenly.
5, the machine during operation, abnormal noise is generated.
1. The shaft knife and the friction part of the machine body are dry and oil-free; 2. There is no oil between the gears.
1. Inject a few drops of clean cooking oil into the oil eye;
2. Apply a small amount of butter to each gear groove.
6 , the heater fails to heat up.
1. The plug is loose or the power cord is off;
Replace the plug of the same specification or repair the power socket;
Five, high pressure machine
The company's plodder, using high-quality refined materials, clean appearance, reliable quality, the use of lightweight, easy to carry.
Sixth, the operation method:
1. Loosen the adjusting screw 1 Move the movable leg 2 to use the size of the pot.
2. Lower the rack 3 to the bottom position of the zui , so that the indenter touches the panel and locks the limit nut 4 to avoid the over-position of the end of the pressing surface.
3. With the pressure bar 5 in the position shown , turn the handle 6 to raise the rack 3 to the high position of the zui.
4. Use the dough tube 7 to the dotted line position to load the pressed material.
5. After the pressed material is installed, move it back to its original position.
6. Turn the handle 6 so that the rack 3 is lowered to the material to be pressed without a gap.
7, hold the handle 6, without reverse gear, lever 5 swings up and down can be suppressed.
8. Rotate the part number 8 to clean the face tube and panel.
 

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[Composition]

The main component of this preparation is human immunoglobulin, which is prepared by cold ethanol fractionation of human plasma from healthy donors. The manufacturing process contains a step to remove anticomplementary activity and a dual viral inactivation process. It contains a suitable amount of glucose or maltose as stabilizer (see table below), but does not contain any antiseptic or antibiotic. The distribution of IgG subclasses is close to the serum level of normal subjects and maintains the bioactivity of Fc fragment of IgG.

[Indications]

1. Primary agammaglobulinemia, such as X-linked hypogammaglobulinemia, common variant immunodeficiency diseases, immunoglobulin G subclass deficiency, etc.

2. Secondary immunoglobulin deficiency diseases, such as severe infection, septicemia of newborn, etc

3. Autoimmune diseases, such as primary thrombocytopenic purpura, Kawasaki disease

Intravenous Injection Of Human Immunoglobulin

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