First, raise a good cow. Undernutrition, severe cow weight loss, will reduce the cow's conception rate. If protein nutrition is lacking, the amount of blood is greatly reduced, so that the supply of nutrients to the pituitary gland and ovary is insufficient, and the secretion of hormones is reduced, so that the cow cannot be in normal oestrus.
Second, high quality semen. To have good quality semen, the sperm motility before freezing should not be less than 0.6; the activity after thawing should not be less than 0.3, and the frozen semen should be thawed at the time when it is used, preferably not more than 1 hour.
Third, the timely insemination, to grasp the cow to grasp the infertility "heat", the mother's steak time is generally 7-10 hours after the termination of estrus, 0-12 hours before ovulation, that is within 3-4 hours after the end of estrus Insemination is most beneficial.
Fourth, skilled in insemination technology. It is necessary to use the rectum to determine the method of insemination, and the site of insemination should reach about 5 cm deep in the cervix.
Fifth, strict operation. In strict accordance with the operating procedures, pay special attention to hygienic conditions, such as the cleaning and disinfection of the vas deferens, the thawing of the thawing liquid, and the disinfection of the genital area of ​​the cow, etc., and you must not neglect any aspect.
Six, pay close attention to compound. Do a good job in the early pregnancy examination of cows, generally 18-20 days after insemination, and 30 days after each pregnancy, perform a pregnancy test once. It is better to do it once again in 40 days. If it is determined that there is no pregnancy, you should find out the cause as soon as possible and take appropriate measures. Look for complexes to increase total pregnancy rate.
LCZ696 (Valsartan/sacubitril) is a combination drug for use in heart failure developed by Novartis. It consists of the angiotensin receptor blocker valsartan and the neprilysin inhibitor sacubitril, in a 1:1 mixture by molecule count. It may be used instead of an ACE inhibitor or an angiotensin receptor blocker in people with heart failure with reduced ejection fraction. The combination is sometimes described as an "angiotensin receptor-neprilysin inhibitor" (ARNi).
It was approved under the FDA's priority review process on July 7, 2015. It is also approved in Europe.
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