Recently, the world's top academic journal Nature has published two major achievements online at the same time. The Shanghai Institute of Materia Medica, Chinese Academy of Sciences led the successful analysis of the three-dimensional structure of the human glucagon receptor full-length protein. The iHuman Institute of Shanghai University of Science and Technology led the successful analysis of the human glucagon-like peptide 1 receptor seven-transmembrane crystal structure. . These two findings provide an important structural biological basis for the development of new drugs for the treatment of type 2 diabetes. In addition, the iHuman Institute led the successful analysis of the multi-domain three-dimensional structure of human smooth receptors, which is an important target for anti-tumor drugs. The result was published yesterday in Beijing, a well-known academic journal, Nature News. All three of these receptors belong to the G protein coupled receptor (GPCR) family. Fudan University is the main partner of these three tasks.
"GPCR people, get the world", this is a sentence often said by Jiang Hualiang, director of the Shanghai Institute of Medicine of the Chinese Academy of Sciences. GPCR is closely related to human diseases and is the largest family of drug target proteins. It consists of 826 members. Currently, more than 40% of listed drugs are targeted by GPCR.
It is not accidental that the three major GPCR results are unveiled. A GPCR research highland is emerging in Zhangjiang. The Shanghai Institute of Materia Medica and the iHuman Institute of Shangke University are the mainstays. The GPCR research clusters closely cooperating with the Fudan University School of Pharmacy and the National New Drug Screening Center are accumulating . A total of 46 GPCR structures were analyzed worldwide, and the research cluster successfully resolved 11 in less than 6 years. The research cluster published 12 research papers in top academic journals such as "Cell", "Nature" and "Science", and developed four related drug candidates, which made China's GPCR structural biology research quickly reach the international advanced level.
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