Modern research
Seeds containing triterpenoid saponin, oil 15%, vitamin A substances. The green part contains alkaloids.
Seeds contain triterpenoid saponin and oil 15%. The green part contains alkaloids. Fruits containing oleanolic acid, 3-o-[β-D-xylo-xylo-xylo (1→3) β-D-glucuronuronic acid]-oleanolic acid, 3-O-[β -D-xylopyrose (1→3) β-D-glucuronopyranoate] - oleanolic acid, 3-O-[β-D-xylopyrose (1→3) β- D-glucuronopyranoic acid]- oleanolic acid-28-O[beta-D-glucopyranose] ester oxime, n-triacontanol, saturated fatty acid mixture, and flavonoids. Still contains volatile oil.
10 Chemical Identification
(1)
Powder tan. Perianth epidermal cell polygonal, stomatal infinitive, parenchyma cells containing calcium oxalate clusters. The pericarp cells are rectangular or polygonal in shape, with thin walls and wavy bends, containing numerous small oxalate crystals. The seed coat cells are tan-colored, polygonal or square-like, shrinking.
(2) Take 1g of this product powder, add methanol 10ml, sonicate for 30 minutes, filter, filtrate as the test solution. Another Kochia saponin Ic reference substance, add methanol to make a solution containing 0.5mg per 1ml as a reference solution. According to the thin layer chromatography (Appendix VIB) test, 5 μl of each of the above two solutions was pipetted onto a thin layer of silica gel G with the same sodium carboxymethyl cellulose as the binder, with chloroform-methanol-water ( 16:9:2) as a developing agent, unfold it, take it out, dry it, spray it with 10% ethanol solution of sulfuric acid, and blow the hot air to the spot to make the color clear. In the chromatogram of the test sample, the same purple-red spot was observed at the position corresponding to the chromatogram of the reference substance.
According to high performance liquid chromatography. Chromatographic conditions and system suitability tests were carried out with octadecylsilane-bonded silica gel as the filler; methanol-water-glacial acetic acid (85:15:0.2) as the mobile phase; and evaporative light scattering detection. The number of theoretical plates should not be less than 3,000 as calculated by Kochia scoparia Ic peak. The preparation of the reference solution was accurately weighed to obtain the appropriate amount of Kochia scoparia Ic reference substance, and methanol was added to prepare a solution containing 0.5 mg per 1 ml, ie, it was obtained. Preparation of the test solution to take this product powder (passing No. 3 sieve) about 0.5g, accurately weighed, placed in stoppered Erlenmeyer flask, accurately add 50ml of methanol, tamponade, weighed, placed overnight, sonication 30 Minutes, cool, and then weighed, with methanol to make up for lost weight, shake, filter, take the filtrate, that is, too. Assay method accurately draws 10 μl of the reference solution and 20 μl of the test solution, 20 μl of the test solution is injected into the liquid chromatograph, measured, and calculated by the logarithmic equation of the two-point method. This product is calculated according to the dry product, containing Kochia scoparia Ic (C41H64O13) shall not be less than 1.8%.
Premix: premix refers to the powder or granular preparation made by the uniform mixture of drug and suitable matrix. The premix was administered through the feed at a certain drug concentration.
Relevant regulations
1. The drugs in the premix should be dried and crushed first. Unless otherwise specified, it shall pass through No. 4 sieve completely, and the mixture of powder that can pass No. 5 sieve shall not exceed 10.0%.
2. The matrix used in the premix includes carrier, diluent, etc. The matrix should be stable, good fluidity, easy to mix with drugs and feed. The fatty matrix should be degreased first. In addition to the substrate specified under each variety, other suitable substrates can also be selected. In general, a single substrate should be used. The matrix shall not contain more than 20 parts per million of heavy metals; Arsenic salt shall not exceed 2 parts per million; The drying loss of inorganic matrix and organic matrix should not exceed 3.0% and 8.0% respectively.
3. According to the property of the drug, the drug can be dispersed evenly by proper methods. Appropriate methods should be used to make the drug mix evenly in the preparation of low concentration drug premix.
4. The premix should have good fluidity and be easy to mix with feed.
5. Unless otherwise specified, the premixes shall be stored in a closed container. The premixes containing volatile drugs or easily hygroscopic drugs shall be stored in a closed container, and the microbial limit shall be controlled.
6. Unless otherwise specified, the label of premix shall also indicate the name of matrix.
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East Africa is Ethiopia, Somalia, Kenya, Tanzania, Uganda, Burundi, Rwanda and Seychelles.
West Africa usually includes Mauritania, Senegal, Gambia, Mali, Burkina Faso, Guinea, Guinea Bissau, Cape Verde, Sierra Leone, Liberia, C ô te d'Ivoire, Ghana, Togo, Benin, Niger, Nigeria, etc.
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Southeast Asia: Myanmar, Thailand, Cambodia, Laos, Vietnam, Philippines, Malaysia, Singapore, Brunei, Indonesia and Timor Leste.
Countries and regions in West Asia include Saudi Arabia, Iran, Iraq, Kuwait, UAE, Oman, Qatar, Bahrain, Turkey, Israel, Palestine, Syria, Lebanon, Jordan, Yemen, Cyprus, Georgia, Armenia and Azerbaijan.
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