Recently, a research report published in the international magazine Cell, researchers from the Australian National University and the University of Heidelberg, Germany, discovered a necessary component in the DNA repair process, which may be a new type of anti-cancer for later development. The drug provides a certain idea.
Researcher Professor Tamas Fischer pointed out that when DNA is damaged, a hybrid structure composed of DNA and RNA plays an important role in repairing genetic information. RNAs are a short copy of genetic information stored in DNA; in the article, researchers It was found that the enzyme-like RNase H, which targets the mixed structure, is critical for the efficient and accurate repair of damaged DNA. The researchers said that the study may provide ideas for the later development of new drugs to target these enzymes, while new drugs can also Regulates the activity of enzymes and blocks or enhances the efficiency of the DNA repair pathway.
The accumulation of mutations in the human genome is often the leading cause of age-related diseases and cancer; the deeper our understanding of DNA repair pathways, the more we can take measures to regulate these repair pathways, and it is likely to develop preventive Measures to reduce the rate of accumulation of multiple mutations.
The enzyme RNase H has been studied for many years and is often used in molecular biology research, but its biological function is currently unclear. The results of this study indicate that the enzyme RNase H is critical for DNA repair. And this function is likely to be an important function of the RNase H enzyme as it is present in every living cell. Finally, the researcher Fischer said, the most surprising thing is that we found a hybrid structure of RNA-DNA (hybrid structure), which was previously thought to negatively affect the integrity of the human genome, but in fact we found in this article This hybrid structure is involved in the DNA protection process.
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