Application of serum pregnancy associated protein-A (PAPP-A) in the treatment of acute coronary syndrome with statin

Application of serum pregnancy associated protein-A (PAPP-A) in the treatment of acute coronary syndrome with statin

(Germany imported from DRG Item No.: EIA2397 Specification: 96T)

Coronary atherosclerotic heart disease, also known as coronary heart disease (CHD), is the most common type of organ disease caused by atherosclerosis and is a common disease that endangers human health. It is extremely urgent to effectively prevent coronary heart disease worldwide.

Researchers generally recognize that inflammation within the plaque is a key factor in plaque instability.

PAPP-A is a zinc-dependent metalloproteinase associated with insulin-like growth factor originally found in the serum of pregnant women. At present, PAPP-A is often used for the screening and diagnosis of congenital chromosomal abnormalities, especially Down's syndrome. Later studies found that PAPP-A can be secreted by different types of cells, and the tissue distribution is very wide. Some researchers have found that PAPP-A is expressed in human vascular smooth muscle cells, extracellular matrix, monocytes and vascular endothelial cells. Recently, foreign studies have found that PAPP-A is abundantly expressed in plaques that are corroded and ruptured, but rarely expressed in stable plaques. This study suggests that PAPP-A is produced by inflammatory cells activated in unstable plaques and released from Intercellular matrix, and can degrade extracellular matrix, participate in the development of atherosclerosis, play an important role in atherosclerotic plaque rupture and vascular wall configuration changes, and considered as ACS (acute coronary syndrome) Sign up for acute coronary syndrome).

For this research, Song Linghua (Shanxi Medical University) made detailed experiments and explanations in his master's thesis. The results showed that the level of PAPP-A was significantly decreased during the treatment of statin patients with acute coronary syndrome, so it can provide a basis for the therapeutic effect of statins.

Http://