Novus helps Hedgehog signaling pathway research

The Hedgehog gene was first discovered in 1980 by Nusslein-Volhard C and Wieschaus E when screening for genes that may cause Drosophila mutations. The Hedgehog (Hh) signaling pathway plays a key role in a variety of physiological processes, such as embryonic development and maintenance of the body environment in adults.
In recent years, many studies have shown that abnormal activation of Hh signaling pathway is involved in various tumor tissues such as basal cell carcinoma, medulloblastoma, lung cancer, digestive tract tumor, and breast cancer , and it is associated with tumor proliferation, differentiation, and apoptosis. , angiogenesis, invasion and metastasis are closely related, suggesting that the abnormal activation of Hh signaling pathway plays an important role in tumorigenesis and development. Blocking Hh signaling pathway in tumors will provide a new and effective way for the treatment of human tumors.

The Hedgehog ( Hh ) signaling pathway is mainly composed of secretory glycoprotein ligand Hedgehog , transmembrane protein receptor Prched ( Ptch ), transmembrane protein Smoothened ( Smo ), nuclear transcription factor Gli protein and downstream target genes. It is generally believed that in the absence of Hh signal peptide, Ptch binds to Smo and inhibits the activity of Smo . The Gli complex will be modified by cleavage to function as a transcriptional repressor in full-length form; when Hh ligand is present, Hh binds to Ptch . To suppress the inhibition of Smo by Ptch , Smo transmits the Hh signal to the cytoplasm, activates the downstream Gli transcription factor, and transfers it into the nucleus in full-length to cause transcription of the target gene. As shown in FIG:

In the whole Hedgehog signaling pathway, Hh protein is a promoter; Ptch protein is a receptor that directly accepts Hh signal on the surface of effector membrane ; Smo protein is a signal transducer, and Gli protein is a transcriptional effector. Hh , Smo and Gli act as agonistic factors and play a positive regulatory role; Ptch acts as an inhibitory factor and exerts a negative regulatory effect. In recent years, research on various factors regulating Hh signaling pathway has become a hot topic in the research field of Hh signaling pathway. As a world-renowned antibody supplier, Novus actively focuses on scientific research and provides you with a large number of high-quality products related to Hedgehog signaling pathway research, which provides convenience for your Hh signaling pathway research. Nouvs Explorer is a bioinformatics tool developed by Novus in cooperation with GeneGo 's GeneGo . It is very convenient for researchers to find interesting research products and references. You can click on the links below to learn more about Hegehog signaling pathway-related genes. Disease, PTMs , query corresponding references. Http://?start_mode=prefilled&entity_name=Hedgehog&entity_type=gene

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Hedgehog Signaling Pathway References:
1. Sahebjam S, et al. The Utility of Hedgehog Signaling Pathway Inhibition for Cancer. Oncologist. 2012 Jul 31. [PMID: 22851551]
2. Ma HY, et al. HSulf-1 suppresses cell growth and down-regulates Hedgehog signaling in human gastric cancer cells. Oncol Lett. 2011 Nov;2(6):1291-1295. [PMID: 22848304].
3. Choi KS, et al. Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs. Mech Dev. 2012 Jul 25. [PMID: 22841806].
4. Riobo NA. Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer. Curr Opin Pharmacol. 2012 Jul 23. [PMID: 22832232].
5. Pan JY, Zhou SH. The hedgehog signaling pathway, a new therapeutic target for treatment of ischemic heart disease. Pharmazie. 2012 Jun;67(6):475-81. [PMID: 22822532].

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